Knockdown of AKT3 Activates HER2 and DDR Kinases in Bone-Seeking Breast Cancer Cells, Promotes Metastasis In Vivo and Attenuates the TGFβ/CTGF Axis

Bone metastases frequently occur in breast cancer patients and lack appropriate treatment options. Hence, understanding the molecular mechanisms involved in the multistep process of breast cancer bone metastasis and tumor-induced osteolysis is of paramount interest. The serine/threonine kinase AKT p...

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Publicat a:Cells
Autors principals: Hinz, Nico, Baranowsky, Anke, Horn, Michael, Kriegs, Malte, Sibbertsen, Freya, Smit, Daniel J., Clezardin, Philippe, Lange, Tobias, Schinke, Thorsten, Jücker, Manfred
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7922044/
https://ncbi.nlm.nih.gov/pubmed/33670586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10020430
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