Systematic Target Screening Revealed That Tif302 Could Be an Off-Target of the Antifungal Terbinafine in Fission Yeast

We used a heterozygous gene deletion library of fission yeasts comprising all essential and non-essential genes for a microarray screening of target genes of the antifungal terbinafine, which inhibits ergosterol synthesis via the Erg1 enzyme. We identified 14 heterozygous strains corresponding to 10...

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Veröffentlicht in:Biomol Ther (Seoul)
Hauptverfasser: Lee, Sol, Nam, Miyoung, Lee, Ah-Reum, Lee, Jaewoong, Woo, Jihye, Kang, Nam Sook, Balupuri, Anand, Lee, Minho, Kim, Seon-Young, Ro, Hyunju, Choi, Youn-Woong, Kim, Dong-Uk, Hoe, Kwang-Lae
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Korean Society of Applied Pharmacology 2021
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7921855/
https://ncbi.nlm.nih.gov/pubmed/33223513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4062/biomolther.2020.166
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