A choreography of centrosomal mRNAs reveals a conserved localization mechanism involving active polysome transport

Local translation allows for a spatial control of gene expression. Here, we use high-throughput smFISH to screen centrosomal protein-coding genes, and we describe 8 human mRNAs accumulating at centrosomes. These mRNAs localize at different stages during cell cycle with a remarkable choreography, ind...

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發表在:Nat Commun
Main Authors: Safieddine, Adham, Coleno, Emeline, Salloum, Soha, Imbert, Arthur, Traboulsi, Abdel-Meneem, Kwon, Oh Sung, Lionneton, Frederic, Georget, Virginie, Robert, Marie-Cécile, Gostan, Thierry, Lecellier, Charles-Henri, Chouaib, Racha, Pichon, Xavier, Le Hir, Hervé, Zibara, Kazem, Mueller, Florian, Walter, Thomas, Peter, Marion, Bertrand, Edouard
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2021
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7921559/
https://ncbi.nlm.nih.gov/pubmed/33649340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21585-7
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