Non-canonical EphA2 signaling is a driver of tumor-endothelial cell interactions and metastatic dissemination in BRAF inhibitor resistant melanoma

Acquired BRAF/MEK inhibitor resistance in melanoma results in a new transcriptional state associated with increased risk of metastasis. Here, we identified non-canonical EphA2 signaling as a driver of the resistance-associated metastatic state. We used mass spectrometry-based proteomic and phenotypi...

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Publicado en:J Invest Dermatol
Main Authors: Zhang, Chao, Smalley, Inna, Emmons, Michael F., Sharma, Ritin, Izumi, Victoria, Messina, Jane, Koomen, John M., Pasquale, Elena B., Forsyth, Peter A., Smalley, Keiran S. M.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7921215/
https://ncbi.nlm.nih.gov/pubmed/32890629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2020.08.012
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