Menin-mediated repression of glycolysis in combination with autophagy protects colon cancer against small molecule EGFR inhibitors

Menin serves both tumor suppressor and promoter roles in a highly tumor-specific manner. In colorectal cancer (CRC) menin is over-expressed and plays a critical role in regulating transcription of SKP2, and combined treatment with a menin inhibitor (MI) and small molecule EGFR inhibitor (EGFRi) lead...

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Veröffentlicht in:Mol Cancer Ther
Hauptverfasser: Katona, Bryson W., Hojnacki, Taylor, Glynn, Rebecca A., Paulosky, Kayla E., Szigety, Katherine M., Cao, Yan, Zhang, Xuyao, Feng, Zijie, He, Xin, Ma, Jian, Hua, Xianxin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7921201/
https://ncbi.nlm.nih.gov/pubmed/32879052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-20-0101
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