Therapeutic Effects of (5R)-5-Hydroxytriptolide on Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via lncRNA WAKMAR2/miR-4478/E2F1/p53 Axis

Rheumatoid arthritis (RA) is an autoimmune disease. Fibroblast-like synoviocytes (FLS) serve a major role in synovial hyperplasia and inflammation in RA. (5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide derivative, shows promising therapeutic effects for RA and is now in phase II clinical trial...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Zhou, Xinpeng, Xie, Duoli, Huang, Jie, Lu, Aiping, Wang, Rongsheng, Jin, Yehua, Zhang, Runrun, Chang, Cen, Xu, Lingxia, Xu, Linshuai, Fan, Junyu, Liang, Chao, He, Dongyi
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7921149/
https://ncbi.nlm.nih.gov/pubmed/33664742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.605616
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