Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production

The human microbiome can produce metabolites that modulate insulin signaling. Type 2 diabetes patients have increased circulating concentrations of the microbially produced histidine metabolite, imidazole propionate (ImP) and administration of ImP in mice resulted in impaired glucose tolerance. Inte...

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Udgivet i:Nat Commun
Main Authors: Venskutonytė, Raminta, Koh, Ara, Stenström, Olof, Khan, Muhammad Tanweer, Lundqvist, Annika, Akke, Mikael, Bäckhed, Fredrik, Lindkvist-Petersson, Karin
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7921117/
https://ncbi.nlm.nih.gov/pubmed/33649331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21548-y
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