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Structural characterization of the microbial enzyme urocanate reductase mediating imidazole propionate production
The human microbiome can produce metabolites that modulate insulin signaling. Type 2 diabetes patients have increased circulating concentrations of the microbially produced histidine metabolite, imidazole propionate (ImP) and administration of ImP in mice resulted in impaired glucose tolerance. Inte...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7921117/ https://ncbi.nlm.nih.gov/pubmed/33649331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21548-y |
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