Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation

Metformin is the first-line therapy for type 2 diabetes, but there are large inter-individual variations in responses to this drug. Its mechanism of action is not fully understood, but activation of AMP-activated protein kinase (AMPK) and changes in the gut microbiota appear to be important. The inh...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Koh, Ara, Mannerås-Holm, Louise, Yunn, Na-Oh, Nilsson, Peter M., Ryu, Sung Ho, Molinaro, Antonio, Perkins, Rosie, Smith, J. Gustav, Bäckhed, Fredrik
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2020
Assuntos:
Short Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7546034/
https://ncbi.nlm.nih.gov/pubmed/32783890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2020.07.012
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