Loss of NRF2 accelerates cognitive decline, exacerbates mitochondrial dysfunction, and is required for the cognitive enhancing effects of Centella asiatica during aging

The water extract of Centella asiatica (CAW) can improve cognitive and mitochondrial function and activate the nuclear factor erythroid 2-related factor 2 (NRF2) regulated antioxidant response pathway in aged mice. Here we investigate whether NRF2 activation is required for the cognitive and mitocho...

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Publicat a:Neurobiol Aging
Autors principals: Zweig, Jonathan A., Brandes, Mikah S., Brumbach, Barbara H., Caruso, Maya, Wright, Kirsten M., Quinn, Joseph F., Soumyanath, Amala, Gray, Nora E.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7920997/
https://ncbi.nlm.nih.gov/pubmed/33486357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2020.11.019
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