Loss of NRF2 accelerates cognitive decline, exacerbates mitochondrial dysfunction, and is required for the cognitive enhancing effects of Centella asiatica during aging

The water extract of Centella asiatica (CAW) can improve cognitive and mitochondrial function and activate the nuclear factor erythroid 2-related factor 2 (NRF2) regulated antioxidant response pathway in aged mice. Here we investigate whether NRF2 activation is required for the cognitive and mitocho...

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Publicado en:Neurobiol Aging
Autores principales: Zweig, Jonathan A., Brandes, Mikah S., Brumbach, Barbara H., Caruso, Maya, Wright, Kirsten M., Quinn, Joseph F., Soumyanath, Amala, Gray, Nora E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7920997/
https://ncbi.nlm.nih.gov/pubmed/33486357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2020.11.019
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