De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2

We developed a de novo protein design strategy to swiftly engineer decoys for neutralizing pathogens that exploit extracellular host proteins to infect the cell. Our pipeline allowed the design, validation, and optimization of de novo human angiotensin-converting enzyme 2 (hACE2) decoys to neutraliz...

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Publicado en:Science
Autores principales: Linsky, Thomas W., Vergara, Renan, Codina, Nuria, Nelson, Jorgen W., Walker, Matthew J., Su, Wen, Barnes, Christopher O., Hsiang, Tien-Ying, Esser-Nobis, Katharina, Yu, Kevin, Reneer, Z. Beau, Hou, Yixuan J., Priya, Tanu, Mitsumoto, Masaya, Pong, Avery, Lau, Uland Y., Mason, Marsha L., Chen, Jerry, Chen, Alex, Berrocal, Tania, Peng, Hong, Clairmont, Nicole S., Castellanos, Javier, Lin, Yu-Ru, Josephson-Day, Anna, Baric, Ralph S., Fuller, Deborah H., Walkey, Carl D., Ross, Ted M., Swanson, Ryan, Bjorkman, Pamela J., Gale, Michael, Blancas-Mejia, Luis M., Yen, Hui-Ling, Silva, Daniel-Adriano
Formato: Artigo
Lenguaje:Inglês
Publicado: American Association for the Advancement of Science 2020
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Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7920261/
https://ncbi.nlm.nih.gov/pubmed/33154107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abe0075
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