De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2

We developed a de novo protein design strategy to swiftly engineer decoys for neutralizing pathogens that exploit extracellular host proteins to infect the cell. Our pipeline allowed the design, validation, and optimization of de novo human angiotensin-converting enzyme 2 (hACE2) decoys to neutraliz...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Linsky, Thomas W., Vergara, Renan, Codina, Nuria, Nelson, Jorgen W., Walker, Matthew J., Su, Wen, Barnes, Christopher O., Hsiang, Tien-Ying, Esser-Nobis, Katharina, Yu, Kevin, Reneer, Z. Beau, Hou, Yixuan J., Priya, Tanu, Mitsumoto, Masaya, Pong, Avery, Lau, Uland Y., Mason, Marsha L., Chen, Jerry, Chen, Alex, Berrocal, Tania, Peng, Hong, Clairmont, Nicole S., Castellanos, Javier, Lin, Yu-Ru, Josephson-Day, Anna, Baric, Ralph S., Fuller, Deborah H., Walkey, Carl D., Ross, Ted M., Swanson, Ryan, Bjorkman, Pamela J., Gale, Michael, Blancas-Mejia, Luis M., Yen, Hui-Ling, Silva, Daniel-Adriano
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7920261/
https://ncbi.nlm.nih.gov/pubmed/33154107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abe0075
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