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Structural basis of substrate selectivity of viperin
Viperin is a radical S-adenosylmethionine (SAM) enzyme that inhibits viral replication by converting cytidine triphosphate (CTP) into 3′-deoxy-3′,4′-didehydro-CTP and by additional undefined mechanisms operating through its N- and C-terminal domains. Here, we describe crystal structures of viperin b...
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| Veröffentlicht in: | Biochemistry |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7920147/ https://ncbi.nlm.nih.gov/pubmed/31917549 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00741 |
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