Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis

Chronic kidney disease (CKD) remains a major epidemiological, clinical, and biomedical challenge. During CKD, renal tubular epithelial cells (TECs) present a persistent inflammatory and profibrotic response. Fatty acid oxidation (FAO), the main source of energy for TECs, is reduced in kidney fibrosis...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Miguel, Verónica, Tituaña, Jessica, Herrero, J. Ignacio, Herrero, Laura, Serra, Dolors, Cuevas, Paula, Barbas, Coral, Puyol, Diego Rodríguez, Márquez-Expósito, Laura, Ruiz-Ortega, Marta, Castillo, Carolina, Sheng, Xin, Susztak, Katalin, Ruiz-Canela, Miguel, Salas-Salvadó, Jordi, González, Miguel A. Martínez, Ortega, Sagrario, Ramos, Ricardo, Lamas, Santiago
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7919728/
https://ncbi.nlm.nih.gov/pubmed/33465052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI140695
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