Endoplasmic reticulum protein TXNDC5 promotes renal fibrosis by enforcing TGF-β signaling in kidney fibroblasts

Renal fibrosis, a common pathological manifestation of virtually all types of chronic kidney disease (CKD), often results in diffuse kidney scarring and predisposes to end-stage renal disease. Currently, there is no effective therapy against renal fibrosis. Recently, our laboratory identified an ER-...

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Vydáno v:J Clin Invest
Hlavní autoři: Chen, Yen-Ting, Jhao, Pei-Yu, Hung, Chen-Ting, Wu, Yueh-Feng, Lin, Sung-Jan, Chiang, Wen-Chih, Lin, Shuei-Liong, Yang, Kai-Chien
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7919722/
https://ncbi.nlm.nih.gov/pubmed/33465051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI143645
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