TGFβ1 neutralization displays therapeutic efficacy through both an immunomodulatory and a non-immune tumor-intrinsic mechanism

BACKGROUND: Transforming growth factor-β (TGFβ) is emerging as a promising target for cancer therapy, given its ability to promote progression of advanced tumors and to suppress anti-tumor immune responses. However, TGFβ also plays multiple roles in normal tissues, particularly during organogenesis,...

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Опубликовано в: :J Immunother Cancer
Главные авторы: Canè, Stefania, Van Snick, Jacques, Uyttenhove, Catherine, Pilotte, Luc, Van den Eynde, Benoit J
Формат: Artigo
Язык:Inglês
Опубликовано: BMJ Publishing Group 2021
Предметы:
Basic Tumor Immunology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7919595/
https://ncbi.nlm.nih.gov/pubmed/33637600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001798
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