Blood-derived mitochondrial DNA copy number is associated with gene expression across multiple tissues and is predictive for incident neurodegenerative disease

Mitochondrial DNA copy number (mtDNA-CN) is a proxy for mitochondrial function and is associated with aging-related diseases. However, it is unclear how mtDNA-CN measured in blood can reflect diseases that primarily manifest in other tissues. Using the Genotype-Tissue Expression Project, we interrog...

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Bibliografske podrobnosti
izdano v:Genome Res
Main Authors: Yang, Stephanie Y., Castellani, Christina A., Longchamps, Ryan J., Pillalamarri, Vamsee K., O'Rourke, Brian, Guallar, Eliseo, Arking, Dan E.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2021
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7919448/
https://ncbi.nlm.nih.gov/pubmed/33441415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.269381.120
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