Elevated Trehalose Levels in C. elegans daf-2 Mutants Increase Stress Resistance, Not Lifespan

The C. elegans insulin/IGF-1 (insulin-like growth factor 1) signaling mutant daf-2 recapitulates the dauer metabolic signature—a shift towards lipid and carbohydrate accumulation—which may be linked to its longevity and stress resistance phenotypes. Trehalose, a disaccharide of glucose, is highly up...

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Gepubliceerd in:Metabolites
Hoofdauteurs: Rasulova, Madina, Zečić, Aleksandra, Monje Moreno, Jose Manuel, Vandemeulebroucke, Lieselot, Dhondt, Ineke, Braeckman, Bart P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7917784/
https://ncbi.nlm.nih.gov/pubmed/33673074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/metabo11020105
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