Movement to the Clinic of Soluble Epoxide Hydrolase Inhibitor EC5026 as an Analgesic for Neuropathic Pain and for Use as a Nonaddictive Opioid Alternative

[Image: see text] This report describes the development of an orally active analgesic that resolves inflammation and neuropathic pain without the addictive potential of opioids. EC5026 acts on the cytochrome P450 branch of the arachidonate cascade to stabilize epoxides of polyunsaturated fatty acids...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Hammock, Bruce D., McReynolds, Cindy B., Wagner, Karen, Buckpitt, Alan, Cortes-Puch, Irene, Croston, Glenn, Lee, Kin Sing Stephen, Yang, Jun, Schmidt, William K., Hwang, Sung Hee
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7917437/
https://ncbi.nlm.nih.gov/pubmed/33550801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c01886
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