Vanillic Acid Reduces Pain-Related Behavior in Knee Osteoarthritis Rats Through the Inhibition of NLRP3 Inflammasome-Related Synovitis

Objectives: Synovitis plays an important role in knee osteoarthritis (KOA) pain. The activation of the NOD-like receptor protein 3 (NLRP3) inflammasome in fibroblast-like synoviocytes (FLSs) promotes KOA development. In this study, we aimed to investigate whether vanillic acid (VA), a monomer derive...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Ma, Zhenyuan, Huang, Zhengquan, Zhang, Li, Li, Xiaochen, Xu, Bo, Xiao, Yancheng, Shi, Xiaoqing, Zhang, Haosheng, Liao, Taiyang, Wang, Peimin
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7917290/
https://ncbi.nlm.nih.gov/pubmed/33658936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.599022
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