Decline in Club Cell Secretory Proteins, Exosomes Induction and Immune Responses to Lung Self-antigens, Kα1 Tubulin and Collagen V, Leading to Chronic Rejection after Human Lung Transplantation

BACKGROUND: Chronic lung allograft dysfunction (CLAD), is a major hurdle for long-term lung allograft survival after lung transplant and roughly 50% of lung transplant recipients (LTxRs) develop CLAD within 5 years. The mechanisms of CLAD development remain unknown. Donor-specific immune responses t...

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Veröffentlicht in:Transplantation
Hauptverfasser: Itabashi, Yoshihiro, Ravichandran, Ranjithkumar, Bansal, Sandhya, Bharat, Ankit, Hachem, Ramsey, Bremner, Ross, Smith, Michael, Mohanakumar, T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7917153/
https://ncbi.nlm.nih.gov/pubmed/32890135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0000000000003428
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