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Variation in Methylmercury Metabolism and Elimination in Humans: Physiological Pharmacokinetic Modeling Highlights the Role of Gut Biotransformation, Skeletal Muscle, and Hair

The biological half-life (t(1/2)) of methylmercury (MeHg) shows considerable individual variability (t(1/2) < 30 to > 120 days), highlighting the importance of mechanisms controlling MeHg metabolism and elimination. Building on a prior physiologically based pharmacokinetic (PBPK) model, we elu...

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Vydáno v:Toxicol Sci
Hlavní autoři: Pope, Quintin, Rand, Matthew D
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7916735/
https://ncbi.nlm.nih.gov/pubmed/33481013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfaa192
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