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Variation in Methylmercury Metabolism and Elimination in Humans: Physiological Pharmacokinetic Modeling Highlights the Role of Gut Biotransformation, Skeletal Muscle, and Hair
The biological half-life (t(1/2)) of methylmercury (MeHg) shows considerable individual variability (t(1/2) < 30 to > 120 days), highlighting the importance of mechanisms controlling MeHg metabolism and elimination. Building on a prior physiologically based pharmacokinetic (PBPK) model, we elu...
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| 出版年: | Toxicol Sci |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7916735/ https://ncbi.nlm.nih.gov/pubmed/33481013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfaa192 |
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