A Novel Triplet-Primed PCR Assay to Detect the Full Range of Trinucleotide CAG Repeats in the Huntingtin Gene (HTT)

The expanded CAG repeat number in HTT gene causes Huntington disease (HD), which is a severe, dominant neurodegenerative illness. The accurate determination of the expanded allele size is crucial to confirm the genetic status in symptomatic and presymptomatic at-risk subjects and avoid genetic polym...

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Vydáno v:Int J Mol Sci
Hlavní autoři: De Luca, Alessandro, Morella, Annunziata, Consoli, Federica, Fanelli, Sergio, Thibert, Julie R., Statt, Sarah, Latham, Gary J., Squitieri, Ferdinando
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7916029/
https://ncbi.nlm.nih.gov/pubmed/33567536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22041689
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