Ouabain-Induced Gene Expression Changes in Human iPSC-Derived Neuron Culture Expressing Dopamine and cAMP-Regulated Phosphoprotein 32 and GABA Receptors

Cardiotonic steroids (CTS) are specific inhibitors and endogenous ligands of a key enzyme in the CNS—the Na(+), K(+)-ATPase, which maintains and creates an ion gradient on the plasma membrane of neurons. CTS cause the activation of various signaling cascades and changes in gene expression in neurons...

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Publié dans:Brain Sci
Auteurs principaux: Lopachev, Alexander V., Lagarkova, Maria A., Lebedeva, Olga S., Ezhova, Margarita A., Kazanskaya, Rogneda B., Timoshina, Yulia A., Khutorova, Anastasiya V., Akkuratov, Evgeny E., Fedorova, Tatiana N., Gainetdinov, Raul R.
Format: Artigo
Langue:Inglês
Publié: MDPI 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7915459/
https://ncbi.nlm.nih.gov/pubmed/33562186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/brainsci11020203
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