Inhibition of Bruton’s tyrosine kinase as a therapeutic strategy for chemoresistant oral squamous cell carcinoma and potential suppression of cancer stemness

Locally advanced oral squamous cell carcinoma (OSCC) requires multimodal therapy, including surgery and concurrent chemoradiotherapy (CCRT). CCRT-resistant and recurrent cancer has a poor prognosis. We investigated the effects of Bruton’s tyrosine kinase (BTK) on CCRT-resistant OSCC tissues. The eff...

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Publicado no:Oncogenesis
Main Authors: Liu, Shao-Cheng, Wu, Yang-Che, Huang, Chih-Ming, Hsieh, Ming-Shou, Huang, Ting-Yi, Huang, Chin-Sheng, Hsu, Tung-Nien, Huang, Mao-Suan, Lee, Wei-Hwa, Yeh, Chi-Tai, Lin, Chun-Shu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7914253/
https://ncbi.nlm.nih.gov/pubmed/33640903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41389-021-00308-z
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