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The APOE gene cluster responds to air pollution factors in mice with coordinated expression of genes that differs by age in humans

Little is known of gene-environment interactions for AD risk factors. Apolipoprotein E (APOE) and neighbors on chromosome 19q13.3 have variants associated with risks of AD, but with unknown mechanism. This study describes a novel link between APOE network, air pollution, and age-related diseases. Mi...

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Bibliografiske detaljer
Udgivet i:Alzheimers Dement
Main Authors: Haghani, Amin, Thorwald, Max, Morgan, Todd E, Finch, Caleb E
Format: Artigo
Sprog:Inglês
Udgivet: 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7914175/
https://ncbi.nlm.nih.gov/pubmed/33215813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/alz.12230
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