NGS-based identification and tracing of microsatellite instability from minute amounts DNA using inter-Alu-PCR

Sensitive detection of microsatellite instability (MSI) in tissue or liquid biopsies using next generation sequencing (NGS) has growing prognostic and predictive applications in cancer. However, the complexities of NGS make it cumbersome as compared to established multiplex-PCR detection of MSI. We...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Yu, Fangyan, Leong, Ka Wai, Makrigiorgos, Alexander, Adalsteinsson, Viktor A, Ladas, Ioannis, Ng, Kimmie, Mamon, Harvey, Makrigiorgos, G Mike
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Methods Online
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7913684/
https://ncbi.nlm.nih.gov/pubmed/33290560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1175
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