mTOR-dependent dysregulation of autophagy contributes to the retinal ganglion cell loss in streptozotocin-induced diabetic retinopathy

BACKGROUND: Neurodegeneration, an early event in the pathogenesis of diabetic retinopathy (DR), precedes clinically detectable microvascular damage. Autophagy dysregulation is considered a potential cause of neuronal cell loss, however underlying mechanisms remain unclear. The mechanistic target of...

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Dettagli Bibliografici
Pubblicato in:Cell Commun Signal
Autori principali: Madrakhimov, Sanjar Batirovich, Yang, Jin Young, Kim, Jin Ha, Han, Jung Woo, Park, Tae Kwann
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2021
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7913405/
https://ncbi.nlm.nih.gov/pubmed/33637094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-00698-4
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