Simulation-Based Assessment of the Impact of Non-Adherence on Endoxifen Target Attainment in Different Tamoxifen Dosing Strategies

Tamoxifen is widely used in breast cancer treatment and minimum steady-state concentrations of its active metabolite endoxifen (C(SS,min ENDX)) above 5.97 ng/mL have been associated with favourable disease outcome. Yet, about 20% of patients do not reach target C(SS,min ENDX) applying conventional t...

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Pubblicato in:Pharmaceuticals (Basel)
Autori principali: Mueller-Schoell, Anna, Klopp-Schulze, Lena, Michelet, Robin, van Dyk, Madelé, Mürdter, Thomas E., Schwab, Matthias, Joerger, Markus, Huisinga, Wilhelm, Mikus, Gerd, Kloft, Charlotte
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7913149/
https://ncbi.nlm.nih.gov/pubmed/33546125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14020115
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