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Simulation-Based Assessment of the Impact of Non-Adherence on Endoxifen Target Attainment in Different Tamoxifen Dosing Strategies
Tamoxifen is widely used in breast cancer treatment and minimum steady-state concentrations of its active metabolite endoxifen (C(SS,min ENDX)) above 5.97 ng/mL have been associated with favourable disease outcome. Yet, about 20% of patients do not reach target C(SS,min ENDX) applying conventional t...
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| Publicado no: | Pharmaceuticals (Basel) |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7913149/ https://ncbi.nlm.nih.gov/pubmed/33546125 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14020115 |
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