Integrated Data Analysis of Six Clinical Studies Points Toward Model-Informed Precision Dosing of Tamoxifen

INTRODUCTION: At tamoxifen standard dosing, ∼20% of breast cancer patients do not reach proposed target endoxifen concentrations >5.97 ng/mL. Thus, better understanding the large interindividual variability in tamoxifen pharmacokinetics (PK) is crucial. By applying non-linear mixed-effects (NLME)...

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發表在:Front Pharmacol
Main Authors: Klopp-Schulze, Lena, Mueller-Schoell, Anna, Neven, Patrick, Koolen, Stijn L. W., Mathijssen, Ron H. J., Joerger, Markus, Kloft, Charlotte
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2020
主題:
Pharmacology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7136483/
https://ncbi.nlm.nih.gov/pubmed/32296331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00283
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