Integrated Data Analysis of Six Clinical Studies Points Toward Model-Informed Precision Dosing of Tamoxifen

INTRODUCTION: At tamoxifen standard dosing, ∼20% of breast cancer patients do not reach proposed target endoxifen concentrations >5.97 ng/mL. Thus, better understanding the large interindividual variability in tamoxifen pharmacokinetics (PK) is crucial. By applying non-linear mixed-effects (NLME)...

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Bibliografske podrobnosti
izdano v:Front Pharmacol
Main Authors: Klopp-Schulze, Lena, Mueller-Schoell, Anna, Neven, Patrick, Koolen, Stijn L. W., Mathijssen, Ron H. J., Joerger, Markus, Kloft, Charlotte
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2020
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7136483/
https://ncbi.nlm.nih.gov/pubmed/32296331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00283
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