Mycobacterium tuberculosis Rv0580c Impedes the Intracellular Survival of Recombinant Mycobacteria, Manipulates the Cytokines, and Induces ER Stress and Apoptosis in Host Macrophages via NF-κB and p38/JNK Signaling

The Mycobacterium tuberculosis (M. tb) genome encodes a large number of hypothetical proteins, which need to investigate their role in physiology, virulence, pathogenesis, and host interaction. To explore the role of hypothetical protein Rv0580c, we constructed the recombinant Mycobacterium smegmati...

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Bibliographic Details
Published in:Pathogens
Main Authors: Ali, Md Kaisar, Nzungize, Lambert, Abbas, Khushnood, Eckzechel, Nzaou Stech Anomene, Abo-kadoum, M. A., Moure, Ulrich Aymard Ekomi, Asaad, Mohammed, Alam, Aftab, Xu, Junqi, Xie, Jianping
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7912736/
https://ncbi.nlm.nih.gov/pubmed/33535567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pathogens10020143
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