Distinct classes of complex structural variation uncovered across thousands of cancer genome graphs

Cancer genomes often harbor hundreds of somatic DNA rearrangement junctions, many of which cannot be easily classified into simple (e.g. deletion) or complex (e.g. chromothripsis) structural variant classes. Applying a novel genome graph computational paradigm to analyze the topology of junction cop...

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I publikationen:Cell
Huvudupphovsmän: Hadi, Kevin, Yao, Xiaotong, Behr, Julie M., Deshpande, Aditya, Xanthopoulakis, Charalampos, Tian, Huasong, Kudman, Sarah, Rosiene, Joel, Darmofal, Madison, DeRose, Joseph, Mortensen, Rick, Adney, Emily M., Shaiber, Alon, Gajic, Zoran, Sigouros, Michael, Eng, Kenneth, Wala, Jeremiah A., Wrzeszczyński, Kazimierz O., Arora, Kanika, Shah, Minita, Emde, Anne-Katrin, Felice, Vanessa, Frank, Mayu O., Darnell, Robert B., Ghandi, Mahmoud, Huang, Franklin, Dewhurst, Sally, Maciejowski, John, De Lange, Titia, Setton, Jeremy, Riaz, Nadeem, Reis-Filho, Jorge S., Powell, Simon, Knowles, David A., Reznik, Ed, Mishra, Bud, Beroukhim, Rameen, Zody, Michael C., Robine, Nicolas, Oman, Kenji M., Sanchez, Carissa A., Kuhner, Mary K., Smith, Lucian P., Galipeau, Patricia C., Paulson, Thomas G., Reid, Brian J., Li, Xiaohong, Wilkes, David, Sboner, Andrea, Mosquera, Juan Miguel, Elemento, Olivier, Imielinski, Marcin
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7912537/
https://ncbi.nlm.nih.gov/pubmed/33007263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.08.006
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