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A New Perspective on the Origin of DNA Double-Strand Breaks and Its Implications for Ageing

It is estimated that 10–50 DNA double-strand breaks (DSBs) occur in a nucleated human cell per cell cycle. We reviewed the present state of knowledge and hypothesized that the currently accepted mechanisms cannot explain such high frequency of DSBs occurring daily under normal physiological conditio...

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Vydáno v:Genes (Basel)
Hlavní autoři: Tripathy, Bhabesh Kumar, Pal, Kavita, Shabrish, Snehal, Mittra, Indraneel
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7912064/
https://ncbi.nlm.nih.gov/pubmed/33530310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes12020163
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