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Do DNA double-strand breaks drive aging?
DNA double-strand breaks (DSBs) are rare but highly toxic lesions, requiring orchestrated and conserved machinery to prevent adverse consequences, such as cell death and cancer-causing genome structural mutations. DSBs trigger the DNA damage response (DDR) that directs a cell to repair the break, un...
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| Pubblicato in: | Mol Cell |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5012315/ https://ncbi.nlm.nih.gov/pubmed/27588601 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.08.004 |
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