Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing

DNA damage has been implicated in ageing, but direct evidence for a causal relationship is lacking, owing to the difficulty of inducing defined DNA lesions in cells and tissues without simultaneously damaging other biomolecules and cellular structures. Here we directly test whether highly toxic DNA...

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Publicado no:Nat Commun
Main Authors: White, Ryan R., Milholland, Brandon, de Bruin, Alain, Curran, Samuel, Laberge, Remi-Martin, van Steeg, Harry, Campisi, Judith, Maslov, Alexander Y., Vijg, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394211/
https://ncbi.nlm.nih.gov/pubmed/25858675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7790
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