Retinal Phenotyping of Ferrochelatase Mutant Mice Reveals Protoporphyrin Accumulation and Reduced Neovascular Response

PURPOSE: Heme depletion, through inhibition of ferrochelatase (FECH), blocks retinal and choroidal neovascularization. Both pharmacologic FECH inhibition and a partial loss-of-function Fech mutation (Fech(m1Pas)) are associated with decreased neovascularization. However, the ocular physiology of Fec...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Invest Ophthalmol Vis Sci
Autori principali: Sardar Pasha, S. P. B., Shetty, Trupti, Lambert-Cheatham, Nathan A., Sishtla, Kamakshi, Mathew, Deepa, Muniyandi, Anbukkarasi, Patwari, Neeta, Bhatwadekar, Ashay D., Corson, Timothy W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Association for Research in Vision and Ophthalmology 2021
Soggetti:
Genetics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7910629/
https://ncbi.nlm.nih.gov/pubmed/33620374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.62.2.36
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