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Heme Synthesis Inhibition Blocks Angiogenesis via Mitochondrial Dysfunction
The relationship between heme metabolism and angiogenesis is poorly understood. The final synthesis of heme occurs in mitochondria, where ferrochelatase (FECH) inserts Fe(2+) into protoporphyrin IX to produce proto-heme IX. We previously showed that FECH inhibition is antiangiogenic in human retinal...
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| Publicado en: | iScience |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Elsevier
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7399258/ https://ncbi.nlm.nih.gov/pubmed/32755804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101391 |
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