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Targeted de-repression of neuronal Nrf2 inhibits α-synuclein accumulation
Many neurodegenerative diseases are associated with neuronal misfolded protein accumulation, indicating a need for proteostasis-promoting strategies. Here we show that de-repressing the transcription factor Nrf2, epigenetically shut-off in early neuronal development, can prevent protein aggregate ac...
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| Publicado no: | Cell Death Dis |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7910424/ https://ncbi.nlm.nih.gov/pubmed/33637689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03507-z |
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