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Targeted de-repression of neuronal Nrf2 inhibits α-synuclein accumulation
Many neurodegenerative diseases are associated with neuronal misfolded protein accumulation, indicating a need for proteostasis-promoting strategies. Here we show that de-repressing the transcription factor Nrf2, epigenetically shut-off in early neuronal development, can prevent protein aggregate ac...
Gorde:
| Argitaratua izan da: | Cell Death Dis |
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| Egile Nagusiak: | , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Nature Publishing Group UK
2021
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7910424/ https://ncbi.nlm.nih.gov/pubmed/33637689 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03507-z |
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