High level of EZH2 expression is linked to high density of CD8-positive T-lymphocytes and an aggressive phenotype in renal cell carcinoma

PURPOSE: Enhancer of zeste homolog 2 (EZH2), the catalytic part of the Polycomb repressive complex 2 (PRC2), has a prognostic role in renal cell carcinoma (RCC) and was recently shown to modulate the immune response by reducing tumor cell immunogenicity. METHODS: To investigate whether the prognosti...

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Vydáno v:World J Urol
Hlavní autoři: Eichenauer, Till, Simmendinger, Luca, Fraune, Christoph, Mandelkow, Tim, Blessin, Niclas C., Kluth, Martina, Hube-Magg, Claudia, Möller, Katharina, Clauditz, Till, Weidemann, Sören, Dahlem, Roland, Fisch, Margit, Riechardt, Silke, Simon, Ronald, Sauter, Guido, Büscheck, Franziska, Rink, Michael
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2020
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7910252/
https://ncbi.nlm.nih.gov/pubmed/32303902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00345-020-03200-4
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