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Combined cellomics and proteomics analysis reveals shared neuronal morphology and molecular pathway phenotypes for multiple schizophrenia risk genes

An enigma in studies of neuropsychiatric disorders is how to translate polygenic risk into disease biology. For schizophrenia, where > 145 significant GWAS loci have been identified and only a few genes directly implicated, addressing this issue is a particular challenge. We used a combined cello...

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Detalhes bibliográficos
Publicado no:Mol Psychiatry
Main Authors: Rosato, Martina, Stringer, Sven, Gebuis, Titia, Paliukhovich, Iryna, Li, Ka Wan, Posthuma, Danielle, Sullivan, Patrick F., Smit, August B., van Kesteren, Ronald E.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7910218/
https://ncbi.nlm.nih.gov/pubmed/31142819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-019-0436-y
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