Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer

CD4 T cells have been implicated in cancer immunity for their helper functions. Moreover, their direct cytotoxic potential has been shown in some patients with cancer. Here, by mining single-cell RNA-seq datasets, we identified CD4 T cell clusters displaying cytotoxic phenotypes in different human c...

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Bibliografske podrobnosti
izdano v:Sci Adv
Main Authors: Cachot, Amélie, Bilous, Mariia, Liu, Yen-Cheng, Li, Xiaokang, Saillard, Margaux, Cenerenti, Mara, Rockinger, Georg Alexander, Wyss, Tania, Guillaume, Philippe, Schmidt, Julien, Genolet, Raphaël, Ercolano, Giuseppe, Protti, Maria Pia, Reith, Walter, Ioannidou, Kalliopi, de Leval, Laurence, Trapani, Joseph A., Coukos, George, Harari, Alexandre, Speiser, Daniel E., Mathis, Alexander, Gfeller, David, Altug, Hatice, Romero, Pedro, Jandus, Camilla
Format: Artigo
Jezik:Inglês
Izdano: American Association for the Advancement of Science 2021
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7909889/
https://ncbi.nlm.nih.gov/pubmed/33637530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe3348
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