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Tumor-specific cytolytic CD4 T cells mediate immunity against human cancer

CD4 T cells have been implicated in cancer immunity for their helper functions. Moreover, their direct cytotoxic potential has been shown in some patients with cancer. Here, by mining single-cell RNA-seq datasets, we identified CD4 T cell clusters displaying cytotoxic phenotypes in different human c...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Cachot, Amélie, Bilous, Mariia, Liu, Yen-Cheng, Li, Xiaokang, Saillard, Margaux, Cenerenti, Mara, Rockinger, Georg Alexander, Wyss, Tania, Guillaume, Philippe, Schmidt, Julien, Genolet, Raphaël, Ercolano, Giuseppe, Protti, Maria Pia, Reith, Walter, Ioannidou, Kalliopi, de Leval, Laurence, Trapani, Joseph A., Coukos, George, Harari, Alexandre, Speiser, Daniel E., Mathis, Alexander, Gfeller, David, Altug, Hatice, Romero, Pedro, Jandus, Camilla
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7909889/
https://ncbi.nlm.nih.gov/pubmed/33637530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe3348
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