Treatment with phosphodiester CpG-ODN ameliorates atopic dermatitis by enhancing TGF-β signaling

Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG phosphorothioate (PS CpG-ODN) are known to decrease IgE synthesis in Th2 allergy responses. Nonetheless, the therapeutic role of PS CpG-ODN is limited due to cytotoxicity. Therefore, we developed a phosphodiester (PO) form of CpG-ODN...

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Veröffentlicht in:BMB Rep
Hauptverfasser: Ham, Won-Kook, Lee, Eun-Jung, Jeon, Myung Shin, Kim, Hae-Young, Agrahari, Gaurav, An, Eun-Joo, Bang, Chul Hwan, Kim, Doo-Sik, Kim, Tae-Yoon
Format: Artigo
Sprache:Inglês
Veröffentlicht: Korean Society for Biochemistry and Molecular Biology 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7907740/
https://ncbi.nlm.nih.gov/pubmed/33612150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5483/BMBRep.2021.54.2.254
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