Multifaceted Mechanism of Amicoumacin A Inhibition of Bacterial Translation

Amicoumacin A (Ami) halts bacterial growth by inhibiting the ribosome during translation. The Ami binding site locates in the vicinity of the E-site codon of mRNA. However, Ami does not clash with mRNA, rather stabilizes it, which is relatively unusual and implies a unique way of translation inhibit...

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Veröffentlicht in:Front Microbiol
Hauptverfasser: Maksimova, Elena M., Vinogradova, Daria S., Osterman, Ilya A., Kasatsky, Pavel S., Nikonov, Oleg S., Milón, Pohl, Dontsova, Olga A., Sergiev, Petr V., Paleskava, Alena, Konevega, Andrey L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2021
Schlagworte:
Microbiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7907450/
https://ncbi.nlm.nih.gov/pubmed/33643246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2021.618857
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