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A glycoside analog of mammalian oligomannose formulated with a TLR4-stimulating adjuvant elicits HIV-1 cross-reactive antibodies

The occurrence of oligomannose-specific broadly neutralizing antibodies (bnAbs) has spurred efforts to develop immunogens that can elicit similar antibodies. Here, we report on the antigenicity and immunogenicity of a CRM(197)-conjugate of a previously reported oligomannose mimetic. Oligomannose-spe...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Bruxelle, Jean-François, Kirilenko, Tess, Trattnig, Nino, Yang, Yiqiu, Cattin, Matteo, Kosma, Paul, Pantophlet, Ralph
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7907241/
https://ncbi.nlm.nih.gov/pubmed/33633304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-84116-w
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