Human BM-MSC secretome enhances human granulosa cell proliferation and steroidogenesis and restores ovarian function in primary ovarian insufficiency mouse model

Primary ovarian insufficiency (POI) is defined as the loss of ovarian function before 40 years of age. It clinically manifests as amenorrhea, infertility, and signs of estrogen insufficiency. POI is frequently induced by chemotherapy. Gonadotoxic chemotherapy reagents damage granulosa cells, which a...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Park, Hang-soo, Chugh, Rishi Man, El Andaloussi, Abdeljabar, Hobeika, Elie, Esfandyari, Sahar, Elsharoud, Amro, Ulin, Mara, Garcia, Natalia, Bilal, Mahmood, Al-Hendy, Ayman
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2021
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7907146/
https://ncbi.nlm.nih.gov/pubmed/33633319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-84216-7
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