Human BM-MSC secretome enhances human granulosa cell proliferation and steroidogenesis and restores ovarian function in primary ovarian insufficiency mouse model

Primary ovarian insufficiency (POI) is defined as the loss of ovarian function before 40 years of age. It clinically manifests as amenorrhea, infertility, and signs of estrogen insufficiency. POI is frequently induced by chemotherapy. Gonadotoxic chemotherapy reagents damage granulosa cells, which a...

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Publicado no:Sci Rep
Main Authors: Park, Hang-soo, Chugh, Rishi Man, El Andaloussi, Abdeljabar, Hobeika, Elie, Esfandyari, Sahar, Elsharoud, Amro, Ulin, Mara, Garcia, Natalia, Bilal, Mahmood, Al-Hendy, Ayman
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7907146/
https://ncbi.nlm.nih.gov/pubmed/33633319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-84216-7
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