Development of thermosensitive resiquimod-loaded liposomes for enhanced cancer immunotherapy

Resiquimod (R848) is a toll-like receptor 7 and 8 (TLR7/8) agonist with potent antitumor and immunostimulatory activity. However, systemic delivery of R848 is poorly tolerated because of its poor solubility in water and systemic immune activation. In order to address these limitations, we developed...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Zhang, Hua, Tang, Wei-Lun, Kheirolomoom, Azadeh, Fite, Brett Z, Wu, Bo, Lau, Kenneth, Baikoghli, Mo, Raie, Marina Nura, Tumbale, Spencer K., Foiret, Josquin, Ingham, Elizabeth S., Mahakian, Lisa M., Tam, Sarah M., Cheng, R. Holland, Borowsky, Alexander D., Ferrara, Katherine W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7906914/
https://ncbi.nlm.nih.gov/pubmed/33189786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2020.11.013
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