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Indole C6 Functionalization of Tryprostatin B Using Prenyltransferase CdpNPT

Tryprostatin A and B are prenylated, tryptophan-containing, diketopiperazine natural products, displaying cytotoxic activity through different mechanisms of action. The presence of the 6-methoxy substituent on the indole moiety of tryprostatin A was shown to be essential for the dual inhibition of t...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Catalysts
Prif Awduron: Gardner, Eric D., Dimas, Dustin A., Finneran, Matthew C., Brown, Sara M., Burgett, Anthony W., Singh, Shanteri
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7906295/
https://ncbi.nlm.nih.gov/pubmed/33643664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/catal10111247
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